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Figure 2 However, significant heterogeneity in EPA/DHA dosing (0.53 g/d) and ratios across studies, short trial durations (typically 6 months), and a lack of robust structural outcome data (e.g., joint space narrowing) have precluded their formal recommendation as a standard adjunctive treatment in clinical guidelines (44)

Izhak L, Wildbaum G, Weinberg U, Uri W, Shaked Y, Alami J, Dumont D, Friedman B, Stein A, Karin N

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Bumetanide and frusemide: qualitative differences (proceedings)